Abstract |
We had previously reported anticancer activity in the water extract (WEX) of Ashwagandha leaves, and identified Triethylene glycol (TEG) as an active tumor suppressor component. In this study, we investigated anti-migratory and anti-angiogenesis activities of WEX and TEG. We conducted in vitro and in vivo experiments using TEG, and its two derivatives, Triethyleneglycol dimethacrylate (TD-10), and Tetraethyleneglycol dimethacrylate (TD-11). The data revealed strong anticancer and anti- metastasis potentials in the derivatives. Non-toxic, anti-migratory doses of the derivatives showed inhibition of canonical Wnt/β- catenin axis and consequent downregulation of EMT-signaling proteins ( Vimentin, MMPs and VEGF). These results endorse that the TD-10 and TD-11 have potential to safely put a check on the aggressiveness of the metastatic cells and therefore represent promising candidates for the treatment of metastatic cancers.
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Authors | Eonju Oh, Sukant Garg, Ye Liu, Sajal Afzal, Ran Gao, Chae-Ok Yun, Sunil C Kaul, Renu Wadhwa |
Journal | Frontiers in oncology
(Front Oncol)
Vol. 8
Pg. 552
( 2018)
ISSN: 2234-943X [Print] Switzerland |
PMID | 30547009
(Publication Type: Journal Article)
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