Comparison of fimasartan and amlodipine therapy on carotid atherosclerotic plaque inflammation.

Abstract

BACKGROUND:

The renin-angiotensin system plays an important role in promoting atherosclerotic plaque inflammation, which may be inhibited by angiotension-II receptor blockers.

HYPOTHESIS:

We investigated the effects of fimasartan and amlodipine therapy on carotid atherosclerotic plaque inflammation using 18 F-fluorodeoxyglucose (18 FDG) positron emission tomography (PET) imaging.

METHODS:

Fifty patients with acute coronary syndrome (ACS) and at least one lesion with 18 FDG uptake in the carotid artery (target-to-background ratio [TBR] ≥ 1.6) were randomly assigned to receive either fimasartan (60 mg once a day) or amlodipine (5 mg once a day). 18 FDG PET examinations were performed in all patients at baseline and 6 months. The primary endpoint was the percent change in the index vessel TBR for the most diseased segment (MDS TBR).

RESULTS:

The two groups had similar baseline characteristics. At the 6-month follow-up, index vessel and aorta MDS TBR significantly decreased in both groups. However, the percent change in index vessel MDS TBR was similar between the two groups (-9.33 ± 14.2% vs -7.73 ± 19.1%, respectively, P = 0.9). No significant difference was found for the percent change in the whole vessel TBR for the index vessel between the two groups, with similar findings for changes in MDS TBR or whole vessel TBR for the aorta. Total cholesterol, low-density lipoprotein cholesterol levels, and blood pressure improved to a similar degree in both groups.

CONCLUSIONS:

Fimasartan and amlodipine reduce carotid atherosclerotic plaque inflammation similarly in patients with ACS, offering the same level of effectiveness.

• Authors: Minyoung Oh, Cheol Whan Lee, Jung-Min Ahn, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Dae Hyuk Moon, Seong-Wook Park, Seung-Jung Park
• Journal: Clinical cardiology (Clin Cardiol) Vol. 42 Issue 2 Pg. 241-246 (Feb 2019) ISSN: 1932-8737 [Electronic] United States
• PMID: 30537083 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: © 2018 The Authors. Clinical Cardiology published by Wiley Periodicals, Inc.

Chemical References

• Biphenyl Compounds
• Calcium Channel Blockers
• Pyrimidines
• Tetrazoles
• Amlodipine
• fimasartan

Topics

• Amlodipine (administration & dosage)
• Biphenyl Compounds (administration & dosage)
• Calcium Channel Blockers (administration & dosage)
• Carotid Arteries (diagnostic imaging)
• Carotid Artery Diseases (diagnosis, drug therapy)
• Dose-Response Relationship, Drug
• Female
• Follow-Up Studies
• Humans
• Inflammation (diagnosis, drug therapy)
• Male
• Middle Aged
• Plaque, Atherosclerotic (diagnosis, drug therapy)
• Positron-Emission Tomography
• Prospective Studies
• Pyrimidines (administration & dosage)
• Tetrazoles (administration & dosage)
• Treatment Outcome