Nationwide registry of sepsis patients in Japan focused on disseminated intravascular coagulation 2011-2013.

Abstract

Sepsis is a syndrome with physiologic, pathologic, and biochemical abnormalities induced by infection. Sepsis can induce the dysregulation of systemic coagulation and fibrinolytic systems, resulting in disseminated intravascular coagulation (DIC), which is associated with a high mortality rate. Although there is no international consensus on available treatments for sepsis-induced DIC, DIC diagnosis and treatment are commonly performed in Japanese clinical settings. Therefore, clinical data related to sepsis-induced DIC diagnosis and treatment can be obtained from Japanese clinical settings. We performed a retrospective nationwide observational study (Japan Septic Disseminated Intravascular Coagulation [J-SEPTIC DIC] study) to collect data regarding characteristics of sepsis patients in Japan, with a focus on coagulofibrinolytic dysregulation and DIC treatment received by each patient. The J-SEPTIC DIC study collected information for a total of 3,195 patients with severe sepsis and septic shock and is the largest data set in Japan on DIC diagnosis and treatment in clinical settings.

• Authors: Mineji Hayakawa, Kazuma Yamakawa, Shinjiro Saito, Shigehiko Uchino, Daisuke Kudo, Yusuke Iizuka, Masamitsu Sanui, Kohei Takimoto, Toshihiko Mayumi
• Journal: Scientific data (Sci Data) Vol. 5 Pg. 180243 (12 11 2018) ISSN: 2052-4463 [Electronic] England
• PMID: 30531950 (Publication Type: Dataset)

Topics

• Disseminated Intravascular Coagulation (complications, diagnosis, epidemiology, therapy)
• Humans
• Japan
• Registries
• Retrospective Studies
• Sepsis (complications, diagnosis, epidemiology, therapy)