Abstract | BACKGROUND: METHODS: We conducted a pilot trial of 43 patients with acute anterior circulation ischemic stroke having EVT. Patients were randomly allocated to receive general anesthesia or conscious sedation. We documented the rate of recruitment and rate of conversion from conscious sedation to general anesthesia. In addition, we recorded the change in National Institute of Health stroke scale (NIHSS) on day 7, the rate of successful reperfusion and measured neurological function by certified researchers using modified Rankin Score (mRS 0 to 2) at 90 days. RESULTS: The recruitment rate was 31.4% and majority of patients were excluded because of delay in hospital presentation and posterior circulation stroke. The rate of conversion from conscious sedation to general anesthesia was 18.2%. This was primarily related to excessive sedation and uncontrolled movement. Change in NIHSS score, rate of successful reperfusion and functional recovery were similar between groups. CONCLUSIONS:
|
Authors | Jian Sun, Fa Liang, Youxuan Wu, Yan Zhao, Zhongrong Miao, Li Zhang, Adrian W Gelb, Matthew T V Chan, Yuming Peng, Ruquan Han, CANVAS Pilot Trial Investigators |
Journal | Journal of neurosurgical anesthesiology
(J Neurosurg Anesthesiol)
Vol. 32
Issue 1
Pg. 41-47
(Jan 2020)
ISSN: 1537-1921 [Electronic] United States |
PMID | 30531556
(Publication Type: Journal Article, Randomized Controlled Trial)
|
Topics |
- Aged
- Anesthesia
(adverse effects, methods)
- Anesthesia, General
(adverse effects, methods)
- Brain Ischemia
(surgery)
- Conscious Sedation
(adverse effects, methods)
- Endovascular Procedures
(methods)
- Female
- Humans
- Male
- Middle Aged
- Pilot Projects
- Recovery of Function
- Reperfusion
- Stroke
(surgery)
- Treatment Outcome
|