Abstract | AIMS: METHODS AND RESULTS: A Markov model was developed to simulate the experiences of a hypothetical population of 1000 individuals with peripheral artery disease or carotid artery disease, profiled on the COMPASS trial, treated with rivaroxaban plus aspirin therapy versus aspirin therapy alone. With each annual cycle, individuals were at risk of having non-fatal cardiovascular disease events, major adverse limb events, or dying. Individuals were also at risk of non-fatal major bleeding. The model had a lifetime time horizon. Costs and utilities were sourced from the literature and discounted at 5.0% annually. Rivaroxaban plus aspirin therapy prevented 143 non-fatal cardiovascular disease events, 118 major adverse limb events and 10 deaths compared to aspirin therapy alone. Conversely, 156 additional major non-fatal bleeds were accrued. With an additional 256 quality-adjusted life years gained, at an additional cost of AUD$6,858,103, the incremental cost-effectiveness ratio was AUD$26,769 (discounted) per quality-adjusted life year gained, which is below Australia's arbitrary willingness to pay threshold of AUD$50,000. CONCLUSION:
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Authors | Ella Zomer, Si Si, Thomas R Hird, Danny Liew, Alice J Owen, Andrew Tonkin, Christopher M Reid, Zanfina Ademi |
Journal | European journal of preventive cardiology
(Eur J Prev Cardiol)
Vol. 26
Issue 8
Pg. 858-868
(05 2019)
ISSN: 2047-4881 [Electronic] England |
PMID | 30526023
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Factor Xa Inhibitors
- Fibrinolytic Agents
- Rivaroxaban
- Aspirin
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Topics |
- Aged
- Aspirin
(administration & dosage, adverse effects, economics)
- Australia
- Carotid Artery Diseases
(diagnosis, drug therapy, economics, mortality)
- Cost-Benefit Analysis
- Decision Support Techniques
- Drug Costs
- Drug Therapy, Combination
- Factor Xa Inhibitors
(administration & dosage, adverse effects, economics)
- Female
- Fibrinolytic Agents
(administration & dosage, adverse effects, economics)
- Hemorrhage
(chemically induced, economics)
- Humans
- Male
- Markov Chains
- Middle Aged
- Models, Economic
- Peripheral Arterial Disease
(diagnosis, drug therapy, economics, mortality)
- Quality of Life
- Quality-Adjusted Life Years
- Recurrence
- Rivaroxaban
(administration & dosage, adverse effects, economics)
- Time Factors
- Treatment Outcome
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