Abstract | BACKGROUND: CASE PRESENTATIONS: Patient 1 is a 72 year-old female with a well-differentiated G3 ileal NET who was incidentally diagnosed with orbital metastases during a hospitalization for pre-septal cellulitis in 2018. Her disease has been controlled with capecitabine rather than local therapy. Patient 2 is a 68 year-old male with a G2 ileal NET who was diagnosed with orbital involvement after developing left peri-orbital swelling in 2017. He was found to have bilateral rectus muscle involvement and was treated with image-guided radiation therapy (IGRT) to both orbits and achieved disease control. Patient 3 is a 63 year-old female with a well-differentiated G3 ileal NET who was incidentally diagnosed with bilateral orbital masses in her recti after undergoing a 68Ga-DOTATATE PET-CT in 2015. She was asymptomatic initially however has now developed diplopia. She will be starting 177Lu-DOTATATE peptide radionuclide receptor therapy (PRRT) shortly. Patient 4 is a 72 year-old male with a grade 2 ileal NET who was incidentally diagnosed with a left lateral rectus metastasis in 2007. This was monitored via surveillance MRI until it began to grow and became symptomatic in 2015. The patient received stereotactic radiation to the site and has been asymptomatic since. Patient 5 is a 61 year-old female with a grade 2 ileal NET who developed progressive diplopia in 2016. Bilateral orbital metastases were noted on orbital MRI and she completed IGRT to the sites shortly thereafter. In the setting of continued growth of the masses she was switched to chemotherapy with capecitabine which has controlled her orbital disease. CONCLUSIONS: NETs can metastasize to the orbits. Orbital disease now often is detected on SSTR-based imaging rather than orbital MRI; when found, it changes treatment approach and surveillance for patients.
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Authors | Satya Das, Gino Pineda, Laura Goff, Rachel Sobel, Jordan Berlin, George Fisher |
Journal | Cancer imaging : the official publication of the International Cancer Imaging Society
(Cancer Imaging)
Vol. 18
Issue 1
Pg. 47
(Dec 06 2018)
ISSN: 1470-7330 [Electronic] England |
PMID | 30522522
(Publication Type: Journal Article)
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Chemical References |
- Organometallic Compounds
- Receptors, Somatostatin
- gallium Ga 68 dotatate
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Topics |
- Aged
- Female
- Humans
- Ileal Neoplasms
(pathology)
- Intestinal Neoplasms
(diagnostic imaging, pathology)
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Neuroendocrine Tumors
(diagnostic imaging, pathology)
- Orbital Neoplasms
(diagnostic imaging, secondary, therapy)
- Organometallic Compounds
- Pancreatic Neoplasms
(diagnostic imaging, pathology)
- Positron Emission Tomography Computed Tomography
- Receptors, Somatostatin
(analysis)
- Stomach Neoplasms
(diagnostic imaging, pathology)
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