Sequence Analysis of the Fusion Protein Gene of Human Respiratory Syncytial Virus Circulating in China from 2003 to 2014.
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| Abstract |
The human respiratory syncytial virus (HRSV) fusion (F) protein is important for HRSV infection, but few studies have examined the genetic diversity of the F gene from Chinese samples. In this study, a total of 330 HRSV F sequences collected from different regions of China between 2003 and 2014 were analyzed to understand their genetic characteristics. In addition, these sequences were compared with 1150 HRSV F sequences in Genbank from 18 other countries. In phylogenetic analysis, Chinese HRSV F sequences sorted into a number of clusters containing sequences from China as well as other countries. F sequences from different genotypes (as determined based on the G gene sequences) within a HRSV subgroup could be found in the same clusters in phylogenetic trees generated based on F gene sequences. Amino acid analysis showed that HRSV F sequences from China and other countries were highly conserved. Of interest, F protein sequences from all Chinese samples were completely conserved at the palivizumab binding site, thus predicting the susceptibility of these strains to this neutralizing antibody. In conclusion, HRSV F sequences from China between 2003 and 2014, similar to those from other countries, were highly conserved.
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| Authors | Jinhua Song, Huiling Wang, Teresa I Ng, Aili Cui, Shuangli Zhu, Yanzhi Huang, Liwei Sun, Zifeng Yang, Deshan Yu, Pengbo Yu, Hong Zhang, Yan Zhang, Wenbo Xu |
| Journal | Scientific reports (Sci Rep) Vol. 8 Issue 1 Pg. 17618 (12 04 2018) ISSN: 2045-2322 [Electronic] England |
| PMID | 30514963 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Chemical References |
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