Palmitic acid methyl ester is a novel neuroprotective agent against cardiac arrest.

Abstract

We previously discovered that palmitic acid methyl ester (PAME) is a potent vasodilator first identified and released from the superior cervical ganglion and remain understudied. Thus, we investigated PAME's role in modulating cerebral blood flow (CBF) and neuroprotection after 6 min of cardiac arrest (model of global cerebral ischemia). Our results suggest that PAME can enhance CBF under normal physiological conditions, while administration of PAME (0.02 mg/kg) immediately after cardiopulmonary resuscitation can also enhance CBF in vivo. Additionally, functional learning and spatial memory assessments (via T-maze) 3 days after asphyxial cardiac arrest (ACA) suggest that PAME-treated rats have improved learning and memory recovery versus ACA alone. Furthermore, improved neuronal survival in the CA1 region of the hippocampus were observed in PAME-treated, ACA-induced rats. Altogether, our findings suggest that PAME can enhance CBF, alleviate neuronal cell death, and promote functional outcomes in the presence of ACA.

• Authors: Reggie Hui-Chao Lee, Alexandre Couto E Silva, HarLee E Possoit, Francesca M Lerner, Po-Yi Chen, Rinata Azizbayeva, Cristiane T Citadin, Celeste Yin-Chieh Wu, Jake T Neumann, Hung Wen Lin
• Journal: Prostaglandins, leukotrienes, and essential fatty acids (Prostaglandins Leukot Essent Fatty Acids) Vol. 147 Pg. 6-14 (08 2019) ISSN: 1532-2823 [Electronic] Scotland
• PMID: 30514597 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2018 Elsevier Ltd. All rights reserved.

Chemical References

• Neuroprotective Agents
• Palmitates
• methyl palmitate

Topics

• Animals
• CA1 Region, Hippocampal (drug effects)
• Cardiopulmonary Resuscitation
• Cerebrovascular Circulation (drug effects)
• Disease Models, Animal
• Heart Arrest (prevention & control, therapy)
• Learning (drug effects)
• Neuroprotective Agents (administration & dosage, pharmacology)
• Palmitates (administration & dosage, pharmacology)
• Rats
• Rats, Sprague-Dawley
• Spatial Memory (drug effects)