Efficacy of sodium glucose cotransporter 2 inhibitors as an adjunct treatment for patients with diabetes type 2.

Abstract

OBJECTIVE:

To analyze the effect of sodium glucose cotransporter 2 (SGLT2) inhibitors in a group of insulin-dependent type 2 diabetes mellitus (T2D) patients.

PATIENTS AND METHODS:

One hundred and five insulin treated T2D patients were enrolled. Primary endpoints were: fasting plasma glucose, HbA1c, weight, total insulin doses (TDI), total basal insulin (TDB) and total rapid insulin (TDR). Secondary variables were: total cholesterol, LDL cholesterol (cLDL), HDL cholesterol (cHDL), triglycerides and systolic (SBP) and diastolic (DBP) blood pressure. Safety and tolerance were evaluated through the appearance of severe hypoglycemia, ketoacidosis and infections.

RESULTS:

After 4 months follow-up, a 0.7 (1.0)% HbA1c reduction was found, accompanied by a -2.8 (11.5) UI/day TDI decrease. Weight dropped for 73.7% of patients, with an average -2.0 (2.7) kg reduction. A global cHDL increase was noted after treatment, while no differences were observed for total cholesterol, triglycerides or cLDL. SBP dropped significantly, but no change in DBP was observed.

CONCLUSION:

The use of SGLT2 inhibitors in insulin treated T2D patients resulted in reduction of HbA1c, which was associated to weight loss, cHDL increase and SBP decrease.

• Authors: Pedro Pujante, Jessica Ares, Carmen Maciá, Raúl Rodriguez Escobedo, Edelmiro Menéndez, Elías Delgado
• Journal: Medicina clinica (Med Clin (Barc)) Vol. 152 Issue 11 Pg. 438-441 (06 07 2019) ISSN: 1578-8989 [Electronic] Spain
• PMID: 30503071 (Publication Type: Journal Article, Multicenter Study, Observational Study)
• Copyright: Published by Elsevier España, S.L.U.

Chemical References

• Benzhydryl Compounds
• Blood Glucose
• Cholesterol, HDL
• Glucosides
• Glycated Hemoglobin A
• Insulin
• Sodium-Glucose Transporter 2 Inhibitors
• hemoglobin A1c protein, human
• Canagliflozin
• dapagliflozin
• empagliflozin

Topics

• Adult
• Aged
• Benzhydryl Compounds (administration & dosage)
• Blood Glucose (drug effects)
• Blood Pressure (drug effects)
• Body Weight (drug effects)
• Canagliflozin (administration & dosage)
• Cholesterol, HDL (drug effects)
• Diabetes Mellitus, Type 2 (drug therapy)
• Female
• Glucosides (administration & dosage)
• Glycated Hemoglobin (drug effects)
• Humans
• Insulin (analysis, therapeutic use)
• Male
• Middle Aged
• Retrospective Studies
• Sodium-Glucose Transporter 2 Inhibitors (administration & dosage)
• Weight Loss (drug effects)