Abstract | BACKGROUND & AIMS: METHODS: We collected data from 2482 participants from the Framingham Heart Study (mean age, 51 ± 11 y; 51% women) who underwent computed tomography and measurement of 14 serum markers of systemic inflammation. Heavy alcohol users were excluded. The liver:phantom ratio (a continuous parameter of liver attenuation relative to a calibration phantom) was used to identify individuals with radiographic evidence of liver fat. Primary covariates included age, sex, smoking, alcohol, aspirin use, hypertension, dyslipidemia, diabetes, and cardiovascular disease. Body mass index and visceral fat were secondary covariates. We used multivariable linear regression models to assess the association between liver fat and systemic inflammatory markers. RESULTS: CONCLUSIONS: In a community-based cohort, individuals with hepatic steatosis without known liver disease had higher mean serum concentrations of systemic markers of inflammation. Studies are needed to determine whether treatment of hepatic steatosis reduces systemic inflammation.
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Authors | Zachary P Fricker, Alison Pedley, Joseph M Massaro, Ramachandran S Vasan, Udo Hoffmann, Emelia J Benjamin, Michelle T Long |
Journal | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
(Clin Gastroenterol Hepatol)
Vol. 17
Issue 6
Pg. 1157-1164.e4
(05 2019)
ISSN: 1542-7714 [Electronic] United States |
PMID | 30476583
(Publication Type: Journal Article, Multicenter Study, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2019 AGA Institute. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- ICAM1 protein, human
- Intercellular Adhesion Molecule-1
- C-Reactive Protein
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Topics |
- Biomarkers
(blood)
- Body Mass Index
- C-Reactive Protein
(metabolism)
- Cardiovascular Diseases
(blood, epidemiology, etiology)
- Disease Progression
- Female
- Humans
- Incidence
- Inflammation
(blood)
- Intercellular Adhesion Molecule-1
(blood)
- Intra-Abdominal Fat
(metabolism)
- Longitudinal Studies
- Male
- Middle Aged
- Multidetector Computed Tomography
(methods)
- Non-alcoholic Fatty Liver Disease
(complications, diagnosis, metabolism)
- Oxidative Stress
- Prognosis
- Risk Factors
- United States
(epidemiology)
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