Multiple Intracranial Meningiomas: A Case Series and Review of the Literature.

Abstract

OBJECTIVE:

To review the published data to create a more comprehensive natural history of multiple meningiomas (MM).

METHODS:

A review of MM published until now was carried out through a Medline search up to August 2018. The use of the "multiple meningiomas" keyword returned 278 articles, and the characteristics analyzed in our present cohort were searched on those publications. Articles without detailed description of clinical findings, neuroimaging confirmation of tumor multiplicity, follow-up at least of 5 years, and clear description of clinical findings were excluded. We added series to this review.

RESULTS:

293 patients with MM were analyzed: 220 women and 73 men, with a total of 932 tumors (3.1 tumors per patient). The majority of tumors were located in the convexity (653% to 74.5%). The total number of tumors treated was 429 (43.9%): 338 (78.8%) by surgical resection and 91 (21.2%) by radiotherapy. Histopathologic description was available in 303 of 429 cases, being grade I in 272 (90.3%) cases, with a predominance of the meningothelial subtype (30.7%). Tumor recurrence was described in 32 (8.07%) among 397 and only 10 deaths (3.4%) of 281 reported cases, where this characteristic was evaluated.

CONCLUSIONS:

World Health Organization grade I predominance was observed among multiple meningiomas in similarity to single meningiomas. Only a fraction of MM patients (43.89%) needed treatment. A benign tumor behavior was corroborated by the observed low frequency of recurrence and mortality.

• Authors: Benedito Jamilson Araújo Pereira, Antônio Nogueira de Almeida, Paulo Henrique Pires de Aguiar, Wellingson Silva Paiva, Manoel Jacobsen Teixeira, Suely Kazue Nagahashi Marie
• Journal: World neurosurgery (World Neurosurg) Vol. 122 Pg. e1536-e1541 (Feb 2019) ISSN: 1878-8769 [Electronic] United States
• PMID: 30471445 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2018 Elsevier Inc. All rights reserved.

Topics

• Adult
• Aged
• Aged, 80 and over
• Cross-Sectional Studies
• Female
• Humans
• Male
• Meningeal Neoplasms (epidemiology, pathology, surgery)
• Meningioma (epidemiology, pathology, surgery)
• Middle Aged
• Neoplasm Grading
• Neoplasm Recurrence, Local
• Neoplasms, Multiple Primary (epidemiology, pathology, surgery)