Radiation-induced dermatitis after administration of mogamulizumab for adult T-cell leukaemia/lymphoma: a multi-institutional retrospective study.

Abstract

BACKGROUND:

Cutaneous adverse reactions are frequently induced by mogamulizumab. Cases of Stevens-Johnson syndrome, toxic epidermal necrolysis and severe photosensitivity related to mogamulizumab have been reported. This study investigated whether severe radiation-induced dermatitis occurred in patients undergoing radiotherapy after the administration of mogamulizumab for adult T-cell leukaemia/lymphoma.

METHODS:

We retrospectively reviewed 46 courses of radiotherapy administered to 15 consecutive patients with adult T-cell leukaemia/lymphoma (acute, n = 7; lymphoma, n = 7; smouldering, n = 1) who received mogamulizumab before or during radiotherapy at three institutions between 2012 and 2017.

RESULTS:

During 43 of the 46 radiotherapy courses, patients developed Grade ≤1 radiation-induced dermatitis. No patient developed Grade ≥3 radiation-induced dermatitis. No patient was prescribed ointments as prophylactic treatment for radiation-induced dermatitis. Development of radiation-induced dermatitis was not significantly associated with the number of days since the administration of mogamulizumab prior to radiotherapy (P = 0.85), frequency of administration of mogamulizumab before/during radiotherapy (P = 0.33), administration of mogamulizumab during radiotherapy (P = 0.41) or types of lesions in adult T-cell leukaemia/lymphoma cases (cutaneous vs. non-cutaneous, P = 0.74). Development of radiation-induced dermatitis was significantly related to the total cutaneous dose (mean, 31.9 Gy [95% confidence interval: 26.6-37.1 Gy] vs. 19.7 Gy [95% confidence interval: 16.2-23.2 Gy], P = 0.0004) and total prescribed dose (mean, 31.5 Gy [95% confidence interval: 26.2-36.8 Gy] vs. 18.5 Gy [95% confidence interval: 15.0-22.0 Gy], P = 0.0002).

CONCLUSION:

None of the 15 patients who received moderate-dose radiotherapy developed severe radiation-induced dermatitis during the 46 courses of radiotherapy after mogamulizumab administration.

• Authors: Hitoshi Maemoto, Takuro Ariga, Takeaki Kusada, Joichi Heianna, Yoshihiko Manabe, Akifumi Miyakawa, Sawako Nakachi, Satoko Morishima, Shiro Iraha, Fumikiyo Ganaha, Hiroaki Masuzaki, Sadayuki Murayama
• Journal: Japanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 49 Issue 2 Pg. 153-159 (Feb 01 2019) ISSN: 1465-3621 [Electronic] England
• PMID: 30452692 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• Antibodies, Monoclonal, Humanized
• mogamulizumab

Topics

• Adult
• Aged
• Antibodies, Monoclonal, Humanized (administration & dosage, adverse effects, therapeutic use)
• Female
• Humans
• Leukemia-Lymphoma, Adult T-Cell (drug therapy, radiotherapy)
• Male
• Middle Aged
• Radiodermatitis (chemically induced, diagnostic imaging)
• Retrospective Studies
• Skin (pathology, radiation effects)
• Survival Analysis