Abstract | PURPOSE: METHODS: Treatment-naïve AMD eyes with (+) complete PVD and without (-) PVD on ultrasonography received three monthly and then pro re nata bevacizumab injections. Best-corrected visual acuity (BCVA) on Snellen charts and optical coherence tomography (OCT) findings were recorded for 12 months. Secondary analysis included PVD definition and group allocation according to OCT baseline scan. RESULTS: Forty-one eyes of 34 patients met the inclusion criteria. At 12 months, median BCVA improved by 0.12 logMAR in the PVD+ group [interquartile range (IQR) -0.52, 0.03, P = 0.140] and remained the same in the PVD- group (IQR -0.12, 0.15, P = 0.643). Median central retinal thickness improved by 43.5 μm and 43 μm in the PVD+ (IQR -143, 3, P = 0.016) and PVD- group (IQR -90, -14, P = 0.008), respectively. All parameters were similar in the two groups at final follow up (P > 0.05). The secondary analysis included 32 eyes of 26 patients and showed no significant differences between the groups at the 12 months endpoint (P > 0.05). CONCLUSION: Our findings show no significant impact of PVD as assessed by ultrasound or by OCT on visual and anatomical outcomes in exudative AMD treated with bevacizumab.
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Authors | Meira Neudorfer, Audelia Eshel Fuhrer, Dinah Zur, Adiel Barak |
Journal | Indian journal of ophthalmology
(Indian J Ophthalmol)
Vol. 66
Issue 12
Pg. 1802-1807
(Dec 2018)
ISSN: 1998-3689 [Electronic] India |
PMID | 30451182
(Publication Type: Journal Article)
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Chemical References |
- Angiogenesis Inhibitors
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- Bevacizumab
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Topics |
- Aged
- Aged, 80 and over
- Angiogenesis Inhibitors
(therapeutic use)
- Bevacizumab
(therapeutic use)
- Cohort Studies
- Female
- Fluorescein Angiography
- Humans
- Intravitreal Injections
- Male
- Prospective Studies
- Tomography, Optical Coherence
- Treatment Outcome
- Ultrasonography
- Vascular Endothelial Growth Factor A
(antagonists & inhibitors)
- Visual Acuity
(physiology)
- Vitreous Detachment
(diagnostic imaging, physiopathology)
- Wet Macular Degeneration
(drug therapy, physiopathology)
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