Experimental Study of the Effectiveness of Phenolic Antioxidants in Male Infertility Caused by Pathospermia.

Abstract

The effect of phenolic antioxidants (dihydroquercetin, p-tyrosol, dibornol) on the morphology, functions, and redox processes in the reproductive cells of male rats was studied on the model of experimental pathospermia. All antioxidants reduced the percentage of degenerative forms of spermatozoa. Dibornol was most effective. Dihydroquercetin and p-tyrosol did not increase the total number of spermatozoa and the percentage of their mobile forms. These indicators were improved only by dibornol. After administration of all test drugs, the antioxidant potential of spermatozoa increased and did not significantly differ from the baseline values.

• Authors: T G Borovskaya, S I Kamalova, N A Krivova, O B Zaeva, M E Poluektova, A V Vychuzhanina, V A Grigor'eva, M B Plotnikov, V E Goldberg
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 166 Issue 1 Pg. 7-10 (Nov 2018) ISSN: 1573-8221 [Electronic] United States
• PMID: 30450526 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Phenols
• 4-hydroxyphenylethanol
• Quercetin
• taxifolin
• Phenylethyl Alcohol

Topics

• Animals
• Antioxidants (therapeutic use)
• Infertility, Male (drug therapy, etiology)
• Male
• Oligospermia (complications, drug therapy)
• Oxidation-Reduction (drug effects)
• Oxidative Stress (drug effects)
• Phenols (therapeutic use)
• Phenylethyl Alcohol (analogs & derivatives, therapeutic use)
• Quercetin (analogs & derivatives)
• Rats
• Rats, Wistar
• Spermatozoa (drug effects)