Non-mercaptalbumin, Oxidized Form of Serum Albumin, Significantly Associated with Renal Function and Anemia in Chronic Kidney Disease Patients.

Abstract

Oxidative stress plays a major role in development of cardiovascular disease in patients with chronic kidney disease (CKD). Human mercaptalbumin (HMA), a reduced form of serum albumin, and non-mercaptalbumin (HNA), an oxidized form of serum albumin, are known as indicators for evaluating oxidative stress in systemic circulation, including end-stage renal disease cases. We investigated factors associated with fraction of HNA [f(HNA)] in 112 pre-dialysis CKD patients (63.6 ± 14.0 years old; 59 males, 53 females) using a newly established anion-exchange column packed with hydrophilic polyvinyl alcohol gel as well as high performance liquid chromatography. Mean f(HNA) in our CKD patients was 30.0 ± 6.1%, higher than that previously reported for healthy subjects. In multiple regression analysis, age (β = 0.200, p = 0.014), eGFR (β = -0.238, p = 0.009), hemoglobin (β = -0.346, p < 0.001), and ferritin (β = 0.200, p = 0.019) were significantly and independently associated with f(HNA) (R2 = 0.356, p < 0.001). In addition, factors related to CKD-mineral and bone disorder (CKD-MBD), including intact-PTH (β = 0.218, p = 0.049) and 1,25-dihydroxyvitamin D (1,25(OH)2D) (β = -0.178, p = 0.040), were significantly and independently associated with serum f(HNA) (R2 = 0.339, p < 0.001), whereas fibroblast growth factor-23 was not. These findings indicate the importance of management of hemoglobin and ferritin levels, as well as appropriate control of CKD-MBD factors for a better redox state of serum albumin in CKD patients.

• Authors: Shinya Nakatani, Keiko Yasukawa, Eiji Ishimura, Ayumi Nakatani, Norikazu Toi, Hideki Uedono, Akihiro Tsuda, Shinsuke Yamada, Hitoshi Ikeda, Katsuhito Mori, Masanori Emoto, Yutaka Yatomi, Masaaki Inaba
• Journal: Scientific reports (Sci Rep) Vol. 8 Issue 1 Pg. 16796 (11 14 2018) ISSN: 2045-2322 [Electronic] England
• PMID: 30429539 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anion Exchange Resins
• Hemoglobins
• Serum Albumin
• mercaptoalbumin
• Ferritins

Topics

• Aged
• Anemia (etiology)
• Anion Exchange Resins
• Chromatography, High Pressure Liquid
• Cross-Sectional Studies
• Female
• Ferritins (blood)
• Glomerular Filtration Rate
• Hemoglobins (analysis)
• Humans
• Male
• Middle Aged
• Oxidation-Reduction
• Oxidative Stress
• Renal Insufficiency, Chronic (complications, diagnosis, metabolism, physiopathology)
• Serum Albumin (analysis, metabolism)