Abstract | PURPOSE: METHODS: 80 patients who underwent curative surgery for colorectal cancer were included into the study. Preoperative serum and intraoperative peritoneal washes CEA and MMP-2 concentrations were measured. RESULTS: Concerning tumor penetration CEA-s and CEA-p concentration was higher in subsequent stages from T2 to T4. Both CEA-s and CEA-p concentration was lower in T2 comparing to T3 and T4. Significant difference of CEA-s and CEA-p was noted between T2 and T4 stages. MMP2-s concentration was higher in T3 comparing to T2, the highest MMP2-p concentration was in T4, with no statistical significance. Concerning nodular status significant difference of CEA-s was noted between N0 and N1. For CEA-p significance was found between N0 and N2 as between N1 and N2. MMP2-s concentration was the highest in N1, MMP2-p concentration was the highest in T4, with no statistical significance. 5-year survival rate for all patients was 63,53%. There were significant differences in CEA-s and CEA-p concentration between patients with negative and positive 5-year survival. CONCLUSION: Intraoperative peritoneal washes concentration of CEA may potentially serve as an important factor for more precise colorectal cancer staging. CEA-p and CEA-s concentration correlates with survival rate in patients suffering from colorectal cancer and can be useful as an additional prognostic factor. Usefulness of MMP2 measurement still requires further studies.
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Authors | Tomasz Guzel, Dagmara Mirowska-Guzel, Gustaw Lech, Marek Wroński, Marzena Iwanowska, Maciej Słodkowski |
Journal | Polski przeglad chirurgiczny
(Pol Przegl Chir)
Vol. 90
Issue 5
Pg. 36-43
(Jun 20 2018)
ISSN: 2299-2847 [Electronic] Poland |
PMID | 30426942
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Carcinoembryonic Antigen
- Matrix Metalloproteinase 2
|
Topics |
- Aged
- Biomarkers, Tumor
(blood)
- Carcinoembryonic Antigen
(blood)
- Colonic Neoplasms
(blood, pathology)
- Colorectal Neoplasms
(blood, pathology)
- Female
- Humans
- Male
- Matrix Metalloproteinase 2
(blood)
- Middle Aged
- Neoplasm Staging
(methods)
- Peritoneum
(chemistry)
- Postoperative Period
- Preoperative Period
- Prognosis
- Survival Rate
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