Mortality and morbidity after pancreatoduodenectomy in patients undergoing hemodialysis: Analysis using a national inpatient database.
Abstract | BACKGROUND: METHODS: We used the Diagnosis Procedure Combination database, a national Japanese inpatient database, to identify patients who underwent pancreatoduodenectomy from July 2010 to March 2015. We conducted propensity-score-matching analyses to compare the outcomes, including postoperative complications and 30- and 90-day mortality after pancreatoduodenectomy between patients with and without hemodialysis. RESULTS: Of 30,495 eligible patients, 307 (1.0%) received hemodialysis. In the unmatched cohort, the proportions of male sex, younger age, pancreatic cancer, ischemic heart disease, diabetes mellitus, and hypertension were greater in patients with hemodialysis than those without hemodialysis. A 1-to-4 propensity score matching created a total of 1,535 patients, including 307 with hemodialysis and 1,228 without hemodialysis. Patients undergoing hemodialysis had greater proportions of postoperative complications, including peritonitis (8.8% vs 4.8%, P = .012), sepsis or disseminated intravascular coagulation (3.6% vs 0.7%, P = .001), intra-abdominal bleeding (4.9% vs 0.7%, P < .001), and acute coronary event (4.2% vs 1.7%, P = .015). Propensity score matching showed that patients undergoing hemodialysis had an increased risk of postoperative complications (OR, 1.62; 95% CI, 1.23-2.14; P = .001), 30-day mortality (OR, 7.45; 95% CI, 3.26-17.0; P < .001), and 90-day mortality (OR, 10.9; 95% CI, 6.58-18.2; P < .001) than those not undergoing hemodialysis. CONCLUSION:
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Authors | Hiroji Shinkawa, Hideo Yasunaga, Kiyoshi Hasegawa, Hiroki Matsui, Nobuaki Michihata, Kiyohide Fushimi, Norihiro Kokudo |
Journal | Surgery
(Surgery)
Vol. 165
Issue 4
Pg. 747-750
(04 2019)
ISSN: 1532-7361 [Electronic] United States |
PMID | 30424925
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2018 Elsevier Ltd. All rights reserved. |
Topics |
- Adult
- Aged
- Aged, 80 and over
- Databases, Factual
- Female
- Humans
- Inpatients
- Logistic Models
- Male
- Middle Aged
- Morbidity
- Pancreaticoduodenectomy
(adverse effects, mortality)
- Postoperative Complications
(etiology)
- Renal Dialysis
(adverse effects)
- Risk
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