The Biological Roles of Translation Initiation Factor 3b.

Abstract

Translation has important roles in almost all physiological and pathological processes, and translation initiation factors are particularly relevant to the translation initiation step, which is the most important step in translation regulation. Translation initiation factor 3b (eIF3b), a key subunit of the largest translation initiation factor 3 (eIF3), is widely considered a scaffold protein that acts to ensure the accuracy of translation initiation. A series of recent finds has revealed that eIF3 is closely related to oncogenesis. However, the concrete mechanism by which eIF3b is involve in carcinogenesis remains elusive. Here, we summarize a series of research findings regarding the relationship between eIF3b, translation and cancer.

• Authors: Xuefei Feng, Juan Li, Peijun Liu
• Journal: International journal of biological sciences (Int J Biol Sci) Vol. 14 Issue 12 Pg. 1630-1635 ( 2018) ISSN: 1449-2288 [Electronic] Australia
• PMID: 30416377 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Eukaryotic Initiation Factor-3

Topics

• Animals
• Carcinogenesis (genetics, metabolism)
• Eukaryotic Initiation Factor-3 (genetics, metabolism)
• Humans
• Neoplasms (genetics, metabolism)