Abstract | BACKGROUND: METHODS: Newly diagnosed subjects with hyperthyroidism undergoing total thyroidectomy (group 1; n = 127) and 131I radioactive iodine therapy (group 2; n = 30) were evaluated for bone mineral density by dual energy x-ray absorptiometry at the time of diagnosis (point A), on achieving euthyroidism with antithyroid drugs (point B), and 6 months after definitive treatment (point C). RESULTS: In group 1, bone mineral density (expressed as g/sq cm; mean ± standard deviation) in the hip (0.842 ± 0.157) and spine (0.97 ± 0.155) at point A, improved at point B (hip, 0.853 ± 0.157 and spine, 0.982 ± 0.155), and further improved at point C (hip, 0.91 ± 0.158 and spine, 1.053 ± 0.161, each P < .001). In group 2, at point C, bone mineral density in the hip (0.761 ± 0.168 versus point A, 0.741 ± 0.146) and spine (0.831 ± 0.159 versus point A, 0.823 ± 0.158) were less than group 1 (each P < .01). CONCLUSION: Bone mineral density improved significantly after all forms of treatment of hyperthyroidism and was greatest in lumbar vertebrae (8.6%) as early as 6 months after total thyroidectomy. The delayed recovery of bone mineral density after 131I radioactive iodine therapy needs long-term evaluation.
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Authors | Poongkodi Karunakaran, Chandrasekaran Maharajan, Rajasekaran Chockalingam, Premkumar Asokumar, Kamaleswaran Koramadai Karuppusamy, Vijay Sadasivam |
Journal | Surgery
(Surgery)
Vol. 165
Issue 1
Pg. 80-84
(01 2019)
ISSN: 1532-7361 [Electronic] United States |
PMID | 30415871
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 Elsevier Inc. All rights reserved. |
Chemical References |
- Antithyroid Agents
- Iodine Radioisotopes
- Carbimazole
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Topics |
- Absorptiometry, Photon
- Adult
- Antithyroid Agents
- Bone Density
(physiology)
- Carbimazole
(therapeutic use)
- Female
- Femur
(diagnostic imaging, physiopathology)
- Humans
- Hyperthyroidism
(physiopathology, therapy)
- Iodine Radioisotopes
(therapeutic use)
- Lumbar Vertebrae
(diagnostic imaging, physiopathology)
- Male
- Middle Aged
- Prospective Studies
- Thyroidectomy
- Young Adult
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