Comparative analysis of the diffusion kurtosis imaging and diffusion tensor imaging in grading gliomas, predicting tumour cell proliferation and IDH-1 gene mutation status.

Abstract

INTRODUCTION:

Few studies have applied diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI) for the comprehensive assessment of gliomas [tumour grade, isocitrate dehydrogenase-1 (IDH-1) mutation status and tumour proliferation rate (Ki-67)]. This study describes the efficacy of DKI and DTI to comprehensively evaluate gliomas, compares their results.

METHODS:

Fifty-two patients (18 females; median age, 47.5 years) with pathologically proved gliomas were prospectively included. All cases underwent DKI examination. DKI (mean kurtosis: MK, axial kurtosis: Ka, radial kurtosis: Kr) and DTI (mean diffusivity: MD, fractional anisotropy: FA) maps of each metric was derived. Three ROIs were manually drawn.

RESULTS:

MK, Ka, Kr and FA were significantly higher in HGGs than in LGGs, whereas MD was significantly lower in HGGs than in LGGs (P < 0.01). ROC analysis demonstrated that MK (specificity: 100% sensitivity: 79%) and Ka (specificity: 96% sensitivity: 82%) had the same and highest (AUC: 0.93) diagnostic value. Moreover, MK, Ka, and Kr were significantly higher in grade III than II gliomas (P ≦ 0.01). Further, DKI and DTI can significantly identify IDH-1 mutation status (P ≦ 0.03). Ka (sensitivity: 74%, specificity: 75%, AUC: 0.72) showed the highest diagnostic value. In addition, DKI metrics and MD showed significant correlations with Ki-67 (P ≦ 0.01) and Ka had the highest correlation coefficient (rs = 0.72).

CONCLUSIONS:

Compared with DTI, DKI has great advantages for the comprehensive assessment of gliomas. Ka might serve as a promising imaging index in predicting glioma grading, tumour cell proliferation rate and IDH-1 gene mutation status.

• Authors: Jing Zhao, Yu-Liang Wang, Xin-Bei Li, Man-Shi Hu, Zhu-Hao Li, Yu-Kun Song, Jing-Yan Wang, Yi-Su Tian, Da-Wei Liu, Xu Yan, Li Jiang, Zhi-Yun Yang, Jian-Ping Chu
• Journal: Journal of neuro-oncology (J Neurooncol) Vol. 141 Issue 1 Pg. 195-203 (Jan 2019) ISSN: 1573-7373 [Electronic] United States
• PMID: 30414095 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Isocitrate Dehydrogenase
• IDH1 protein, human

Topics

• Adult
• Aged
• Brain Neoplasms (diagnostic imaging, genetics, pathology)
• Cell Proliferation
• Diffusion Magnetic Resonance Imaging
• Diffusion Tensor Imaging
• Female
• Glioma (diagnostic imaging, genetics, pathology)
• Humans
• Isocitrate Dehydrogenase (genetics)
• Male
• Middle Aged
• Mutation
• Neoplasm Grading
• Prospective Studies
• Sensitivity and Specificity
• Young Adult