Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells.

Abstract

Prostate carcinoma causes a great number of deaths every year; therefore, there is an urgent need to find new drug candidates to treat advanced prostate cancer. Isobavachalcone (IBC) is the chalcone composition of Psoralea corylifolia Linn used in traditional Chinese medicine. Although IBC demonstrates potent anticancer efficacy in numerous types of human cancer cells, the cellular targets of IBC have not been fully defined. In our study, we found that IBC may induce reactive oxygen species- (ROS-) mediated apoptosis via interaction with a selenocysteine (Sec) containing the antioxidant enzyme thioredoxin reductase 1 (TrxR1), and induce lethal endoplasmic reticulum (ER) stress by inhibiting TrxR1 activity and increasing ROS levels in human prostate cancer PC-3 cells. Furthermore, we also observed that knocking down TrxR1 would sensitized cancer cells to IBC treatment. Our study provides evidence for the anticancer mechanism of IBC with TrxR1 as a potential target.

• Authors: Kai Li, Qiusheng Zheng, Xiaoyu Chen, Yunchao Wang, Dan Wang, Jianning Wang
• Journal: Oxidative medicine and cellular longevity (Oxid Med Cell Longev) Vol. 2018 Pg. 1915828 ( 2018) ISSN: 1942-0994 [Electronic] United States
• PMID: 30410640 (Publication Type: Journal Article)

Chemical References

• Chalcones
• Reactive Oxygen Species
• isobavachalcone
• Thioredoxin Reductase 1

Topics

• Apoptosis (drug effects)
• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Cell Shape (drug effects)
• Chalcones (pharmacology, therapeutic use)
• Endoplasmic Reticulum Stress (drug effects)
• Enzyme Activation (drug effects)
• Humans
• Male
• Prostatic Neoplasms (drug therapy, metabolism, pathology)
• Reactive Oxygen Species (metabolism)
• Signal Transduction (drug effects)
• Thioredoxin Reductase 1 (metabolism)