Malignant Transformation of Testicular Teratoma to PNET, Adenocarcinoma, and Osteosarcoma with Complete Remission after Surgery and Combination Chemotherapy in a Young Adult Male.

Abstract

Mixed germ cell tumors (GCT) with teratoma components can transform into somatic malignancies which can include histologies outside of traditional germ cell lineages. We describe a case of an 18-year-old man with a metastatic testicular GCT with both mature and immature teratoma components containing malignant transformation into multiple histologies including PNET in the primary testicular tumor and osteosarcoma in a separate pulmonary metastatic lesion. Management with targeted chemotherapy resulted in a durable remission. This is the first reported case that we know of a patient with primary PNET malignant transformation with subsequent metastatic transformation to osteosarcoma.

• Authors: Angela Shaw, Miriam Morrell, Annikka Weissferdt, Andrea Hayes-Jordan, Douglas Harrison
• Journal: Case reports in oncological medicine (Case Rep Oncol Med) Vol. 2018 Pg. 8460603 ( 2018) ISSN: 2090-6706 [Print] United States
• PMID: 30402315 (Publication Type: Case Reports)