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CRISPR/Cas9 offers a new tool for studying the role of chromatin architecture in disease pathogenesis.

Abstract
A recent study used CRISPR/Cas9 to reveal long-range looping between disease-related genes and their regulatory elements that is mediated by the CCCTC-binding factor (CTCF) in prostate cancer.
AuthorsXiang Guo, Ann Dean
JournalGenome biology (Genome Biol) Vol. 19 Issue 1 Pg. 185 (11 06 2018) ISSN: 1474-760X [Electronic] England
PMID30400943 (Publication Type: Journal Article, Research Support, N.I.H., Intramural)
Chemical References
  • CCCTC-Binding Factor
  • CTCF protein, human
  • Chromatin
Topics
  • CCCTC-Binding Factor (genetics, metabolism)
  • CRISPR-Cas Systems
  • Chromatin
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Male
  • Prostatic Neoplasms (genetics, pathology)
  • Protein Binding
  • Regulatory Elements, Transcriptional

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