Studies on the polyoma tumor-specific transplantation antigen (TSTA): selection and characterization of TSTA-negative segregants from somatic hybrids.

Abstract

Two polyoma-TSTA-negative variants were selected independently from a polyoma fibrosarcoma/Moloney lymphoma somatic hybrid, by repeated passages in polyoma-virus-preimmunized mice. One of the variants had lost all its polyoma DNA, while the other only retained a deleted piece of its integrated polyoma DNA. In contrast to the parental hybrid clone, none of the variants produced detectable amounts of T-antigens. This finding indicates that a detectable expression of the products of the polyoma virus early genome, the T-antigens, is important either directly or indirectly for the expression of TSTA.

• Authors: T Ramqvist, G Reinholdsson, R Szigeti, G Klein, T Dalianis
• Journal: International journal of cancer (Int J Cancer) Vol. 40 Issue 1 Pg. 74-80 (Jul 15 1987) ISSN: 0020-7136 [Print] United States
• PMID: 3036722 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens, Neoplasm
• DNA, Viral
• Histocompatibility Antigens
• tumor-associated transplantation antigen

Topics

• Animals
• Antigens, Neoplasm (analysis)
• Chromosome Deletion
• Clone Cells (analysis)
• DNA, Viral (analysis)
• Histocompatibility Antigens (analysis)
• Hybrid Cells (analysis)
• Mice
• Mice, Inbred CBA
• Polyomavirus
• Tumor Virus Infections (analysis)