Carbon-ion radiotherapy for locally recurrent rectal cancer: Japan Carbon-ion Radiation Oncology Study Group (J-CROS) Study 1404 Rectum.

Abstract

PURPOSE:

We investigated the efficacy and safety of carbon-ion radiotherapy (C-ion RT) for locally recurrent rectal cancer (LRRC).

PATIENTS AND METHODS:

Data from patients with LRRC treated with C-ion RT from November 2003 to December 2014 at three institutions were retrospectively analyzed. The endpoints of this clinical trial were overall survival (OS), local control (LC), and acute/late toxicity.

RESULTS:

A total of 224 patients' data were collected. The prescribed dose was 70.4 Gy (relative biological effectiveness [RBE]-weighted absorbed dose) or 73.6 Gy (RBE) in 16 fractions. The median follow-up period from the initiation of C-ion RT was 62 months (range 6-169 months). The OS rates were 73% (95% confidence interval [CI], 67%-79%) at 3 years and 51% (95%CI 44%-58%) at 5 years. The LC rates were 93% (95%CI 88%-96%) at 3 years, and 88% (95%CI 82%-93%) at 5 years. Grade 3 acute toxicity was observed in three patients: gastrointestinal toxicity (n = 1) and pelvic infection (n = 2). Grade 3 late toxicity was observed in 12 patients: skin reaction (n = 2), gastrointestinal toxicity (n = 2), neuropathy (n = 1), and pelvic infection (n = 7). There was no grade 4 or 5 acute or late toxicity.

CONCLUSIONS:

This first multi-institutional analysis of C-ion RT for LRRC indicated relatively favorable outcomes with limited toxicities.

• Authors: Makoto Shinoto, Shigeru Yamada, Masahiko Okamoto, Yoshiyuki Shioyama, Tatsuya Ohno, Takashi Nakano, Kenji Nemoto, Yuka Isozaki, Shohei Kawashiro, Hiroshi Tsuji, Tadashi Kamada
• Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (Radiother Oncol) Vol. 132 Pg. 236-240 (03 2019) ISSN: 1879-0887 [Electronic] Ireland
• PMID: 30360998 (Publication Type: Journal Article, Multicenter Study)
• Copyright: Copyright © 2018 Elsevier B.V. All rights reserved.

Topics

• Adult
• Aged
• Aged, 80 and over
• Female
• Gastrointestinal Tract (radiation effects)
• Heavy Ion Radiotherapy (adverse effects, methods)
• Humans
• Male
• Middle Aged
• Neoplasm Recurrence, Local (radiotherapy)
• Radiation Injuries (etiology)
• Rectal Neoplasms (radiotherapy)
• Relative Biological Effectiveness
• Retrospective Studies
• Survival Rate