Tumor Targeting and Tumor Growth Inhibition Capability of Mesoporous Silica Nanoparticles in Mouse Models.

Abstract

Mesoporous silica nanoparticles (MSNs) provide a promising vehicle for anticancer drug delivery. Various animal studies point to the efficacy of this nanoparticle for delivering anticancer agents (drug and siRNA) to inhibit tumor growth. These studies also showed tumor accumulation of MSN nanoparticles. While the extent of tumor accumulation differed, the study showed that it is possible to achieve significant accumulation of nanoparticles in the tumor. Biocompatibility and safety of MSN were also demonstrated by these studies.

• Authors: Tan Le Hoang Doan, Ngoc Xuan Dat Mai, Kotaro Matsumoto, Fuyuhiko Tamanoi
• Journal: The Enzymes (Enzymes) 2018 Vol. 44 Pg. 61-82 ISSN: 0423-2607 [Print] United States
• PMID: 30360815 (Publication Type: Journal Article)
• Copyright: © 2018 Elsevier Inc. All rights reserved.

Chemical References

• RNA, Small Interfering
• Silicon Dioxide

Topics

• Animals
• Drug Delivery Systems
• Mice
• Models, Animal
• Nanoparticles (administration & dosage, chemistry)
• Neoplasms (drug therapy, genetics, metabolism)
• RNA, Small Interfering (administration & dosage)
• Silicon Dioxide (administration & dosage, chemistry, pharmacokinetics)