Radiological Features of Programmed Cell Death-Ligand 2-positive Lung Adenocarcinoma: A Single-institution Retrospective Study.

Abstract

AIM:

Programmed cell death-ligand 1 and 2 (PD-L1 and PD-L2) are ligands of the programmed cell death-1 (PD1) receptor. PD1/PD-L1 inhibitors have shown clinical efficacy in non-small cell lung cancer (NSCLC). However, relatively little is known about the expression of PD-L2, or its association with the clinicopathological features of NSCLC. Here, the radiological features of PD-L2-positive lung adenocarcinoma were evaluated.

MATERIALS AND METHODS:

PD-L1 and PD-L2 expression were evaluated by immunohistochemical staining of surgically-resected specimens from 393 patients with primary lung adenocarcinoma who underwent preoperative thin-section computed tomography (CT), 222 of whom also underwent 18F-fluorodeoxyglucose positron-emission tomography/CT (18F-FDG-PET/CT).

RESULTS:

Among the 393 specimens, 132 (33.6%) and 266 (67.7%) were positive for PD-L1 and PD-L2 expression, respectively. Multivariate analysis showed that the absence of surrounding ground glass opacity and the presence of air bronchogram were significantly associated with PD-L2 expression; however, there was no significant association between PD-L2 expression and the consolidation/tumor ratio. In 222 18F-FDG-PET/CT, the maximum standardized uptake value was significantly higher in patients with PD-L2-positive compared to those with PD-L2-negative tumors.

CONCLUSION:

PD-L2-positive lung adenocarcinomas are less radiologically malignant and invasive than their PD-L1-positive counterparts.

• Authors: Kazuki Takada, Gouji Toyokawa, Koichi Azuma, Shinkichi Takamori, Tomoko Jogo, Fumihiko Hirai, Tetsuzo Tagawa, Akihiko Kawahara, Jun Akiba, Isamu Okamoto, Yoichi Nakanishi, Yoshinao Oda, Tomoaki Hoshino, Yoshihiko Maehara
• Journal: In vivo (Athens, Greece) (In Vivo) 2018 Nov-Dec Vol. 32 Issue 6 Pg. 1541-1550 ISSN: 1791-7549 [Electronic] Greece
• PMID: 30348714 (Publication Type: Journal Article)
• Copyright: Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• B7-H1 Antigen
• Biomarkers, Tumor
• CD274 protein, human
• PDCD1 protein, human
• PDCD1LG2 protein, human
• Programmed Cell Death 1 Ligand 2 Protein
• Programmed Cell Death 1 Receptor
• Fluorodeoxyglucose F18

Topics

• Adenocarcinoma of Lung (diagnostic imaging, genetics, pathology)
• Adult
• Aged
• Aged, 80 and over
• B7-H1 Antigen (genetics)
• Biomarkers, Tumor (genetics)
• Female
• Fluorodeoxyglucose F18 (administration & dosage)
• Gene Expression Regulation, Neoplastic (genetics)
• Humans
• Male
• Neoplasm Invasiveness (genetics, pathology)
• Positron Emission Tomography Computed Tomography
• Programmed Cell Death 1 Ligand 2 Protein (genetics)
• Programmed Cell Death 1 Receptor (genetics)