Oestradiol 16 alpha-hydroxylase: a risk marker for breast cancer.

Abstract

17-oxidation and 2- and 16 alpha-hydroxylation of oestradiol show important correlations with biological aspects of breast cancer in women and mice. The presence of mouse mammary tumour virus may lead to increased 16 alpha-hydroxylation. 16 alpha-hydroxyoestrone (which may be generated in an autocrine manner) forms covalent linkages with amino groups on proteins and nucleotides.

• Authors: H L Bradlow, R E Hershcopf, J F Fishman
• Journal: Cancer surveys (Cancer Surv) Vol. 5 Issue 3 Pg. 573-83 ( 1986) ISSN: 0261-2429 [Print] United States
• PMID: 3034420 (Publication Type: Journal Article, Review)

Chemical References

• Estrogens
• Steroid Hydroxylases
• Aryl Hydrocarbon Hydroxylases
• Steroid 16-alpha-Hydroxylase

Topics

• Animals
• Aryl Hydrocarbon Hydroxylases
• Breast Neoplasms (enzymology)
• Estrogens (metabolism)
• Female
• Humans
• Male
• Mammary Neoplasms, Experimental (enzymology)
• Mammary Tumor Virus, Mouse
• Menopause
• Mice
• Mice, Inbred Strains
• Risk
• Steroid 16-alpha-Hydroxylase
• Steroid Hydroxylases (analysis)