[HL-A D antigens from B-lymphocytes and susceptibility to certain diseases].

Abstract

The discovery of many associations between HLA and human diseases has emphasized the biologic importance of the main histocompatibility system in man. The recent findings from specific immune response genes (Ir locus) mapping within the H2 region of the mouse have led to systematic study of the similar D locus mapping within the HLA region in man. In this study the frequency of a number of HLA-D antigens has been determined in normal individuals and in patients with four diseases selected in view of their genetic background: juvenile diabetes, multiple sclerosis, grass pollinosis and acute leukemia. In each a significant association has been found with a specific HLA-D antigen: DW3 in juvenile diabetes and grass pollinosis, DW2 in multiple sclerosis, and DW7 in acute lymphoblastic leukemia.

• Authors: P de Moerloose, X Chardonnens, P Vassalli, M Jeannet
• Journal: Schweizerische medizinische Wochenschrift (Schweiz Med Wochenschr) Vol. 107 Issue 41 Pg. 1461 (Oct 15 1977) ISSN: 0036-7672 [Print] Switzerland
• Vernacular Title: Antigènes HLA-D des lymphocytes B et susceptibilité à certaines maladies.
• PMID: 303374 (Publication Type: English Abstract, Journal Article)

Chemical References

• HLA Antigens

Topics

• B-Lymphocytes (immunology)
• Chromosome Mapping
• Diabetes Mellitus, Type 1 (immunology)
• HLA Antigens
• Humans
• Immunogenetics
• Leukemia, Lymphoid (immunology)
• Multiple Sclerosis (immunology)
• Rhinitis, Allergic, Seasonal (immunology)