Abstract |
The problem of antibiotic resistance among pathogens encourages searching for novel active molecules. The aim of the research was to assay the anti-quorum sensing (anti-QS) and antibiofilm potential of Melaleuca alternifolia essential oil and its main constituent, terpinen-4-ol, to prevent the infections due to methicillin-resistant Staphylococcus aureus strains as an alternate to antibiotics. The tea tree oil (TTO) was evaluated for its potential in inhibiting QS-dependent phenomena such as violacein production in Chromobacterium violaceum, swarming motility of Pseudomonas aeruginosa PAO1, and biofilm formation in MRSA strains on glass. The results showed that terpinen-4-ol was able to inhibit MRSA strain biofilm formation on the glass strips by 73.70%. TTO inhibited the violacein production at a mean inhibitory concentration (MIC) value of 0.048 mg/mL by 69.3%. At 100 µg/mL TTO and terpinen-4-ol exhibited inhibition in swarming motility of PAO1 by 33.33% and 25%, respectively. TTO revealed anti-QS and anti-biofilm activities at very low concentrations, but it could be further investigated for new molecules useful for the treatment of MRSA infections.
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Authors | Emira Noumi, Abderrahmen Merghni, Mousa M Alreshidi, Ons Haddad, Gültekin Akmadar, Laura De Martino, Maha Mastouri, Ozgur Ceylan, Mejdi Snoussi, Abdulbasit Al-Sieni, Vincenzo De Feo |
Journal | Molecules (Basel, Switzerland)
(Molecules)
Vol. 23
Issue 10
(Oct 17 2018)
ISSN: 1420-3049 [Electronic] Switzerland |
PMID | 30336602
(Publication Type: Journal Article)
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Chemical References |
- Oils, Volatile
- Plant Extracts
- Terpenes
- terpinenol-4
- Tea Tree Oil
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Topics |
- Biofilms
(drug effects)
- Chromobacterium
(drug effects, pathogenicity)
- Humans
- Melaleuca
(chemistry)
- Methicillin-Resistant Staphylococcus aureus
(drug effects, pathogenicity)
- Oils, Volatile
(chemistry, pharmacology)
- Plant Extracts
(chemistry, pharmacology)
- Pseudomonas aeruginosa
(drug effects, pathogenicity)
- Quorum Sensing
(drug effects)
- Staphylococcal Infections
(drug therapy, microbiology)
- Tea Tree Oil
(pharmacology)
- Terpenes
(chemistry, pharmacology)
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