The Influence of CYP3A4 Polymorphism in Sex Steroids as a Risk Factor for Breast Cancer.

Abstract

OBJECTIVE:

 Epidemiological studies have shown evidence of the effect of sex hormones in the pathogenesis of breast cancer, and have suggested a relationship of the disease with variations in genes involved in estrogen synthesis and/or metabolism. The aim of the present study was to evaluate the association between the CYP3A4*1B gene polymorphism (rs2740574) and the risk of developing breast cancer.

METHODS:

 In the present case-control study, the frequency of the CYP3A4*1B gene polymorphism was determined in 148 women with breast cancer and in 245 women without the disease. The DNA of the participants was extracted from plasma samples, and the gene was amplified by polymerase chain reaction. The presence of the polymorphism was determined using restriction enzymes.

RESULTS:

 After adjusting for confounding variables, we have found that the polymorphism was not associated with the occurrence of breast cancer (odds ratio = 1.151; 95% confidence interval: 0.714-1.856; p = 0.564). We have also found no association with the presence of hormone receptors, with human epidermal growth factor receptor 2 (HER2) overexpression, or with the rate of tumor cell proliferation.

CONCLUSION:

 We have not observed a relationship between the CYP3A4*1B gene polymorphism and the occurrence of breast cancer.

• Authors: Melissa Gonzalez Veiga, Rogério Tadeu Felizi, Dayane Guerino Reis, Ivo Carelli Filho, Cesar Eduardo Fernandes, Ricardo Peres do Souto, Emerson Oliveira
• Journal: Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia (Rev Bras Ginecol Obstet) Vol. 40 Issue 11 Pg. 699-704 (Nov 2018) ISSN: 1806-9339 [Electronic] Brazil
• Vernacular Title: Influência do polimorfismo do gene CYP3A4 nos esteroides sexuais como fator de risco para câncer de mama.
• PMID: 30336495 (Publication Type: Journal Article)
• Copyright: Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil.

Chemical References

• Gonadal Steroid Hormones
• Cytochrome P-450 CYP3A
• CYP3A4 protein, human

Topics

• Breast Neoplasms (epidemiology, etiology, genetics)
• Case-Control Studies
• Cross-Sectional Studies
• Cytochrome P-450 CYP3A (genetics)
• Female
• Gonadal Steroid Hormones (physiology)
• Humans
• Middle Aged
• Polymorphism, Genetic
• Risk Factors