Abstract | BACKGROUND: PATIENTS AND METHODS: 84 hemodialysis patients were enrolled. Data collection included chart reviews and assessments of laboratory records. PF4-H Ab was evaluated by ELISA and a titer ≥ 0.4 was defined to have PF4-H Ab. RESULTS: 30 patients were PF4-H Ab positive, 30 patients had CAD, 29 patients had IS, and 43 patients had AVFT. In Cox proportional hazard regression analysis, PF4-H Ab (HR 2.72, p = 0.01) was a significant risk factor for CAD. Age (HR 1.06, p = 0.003), PF4-H Ab (HR 4.53, p < 0.001), 7-year averaged serum phosphate levels (HR 0.53, p = 0.012), and 7-year averaged blood platelet count (HR 1.01, p = 0.029) were risk factors for IS. Age (HR 1.03, p = 0.047), PF4-H Ab (HR 3.57, p < 0.001), and 7-year averaged serum triglyceride levels (HR 1.01, p = 0.005) were risk factors for AVFT. In PF4-H Ab-positive groups, thrombocytopenia was not associated with CAD, IS, and AVFT by Fisher's test analysis. CONCLUSION: This study reveals that PF4-H Ab is a risk factor for developing CAD, IS, and AVFT among hemodialysis patients.
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Authors | Chi-Chu Liu, Li-Ping Chou, Tsang-Shan Chen, Chien-An Chen, Yueh-Feng Tsai |
Journal | International urology and nephrology
(Int Urol Nephrol)
Vol. 50
Issue 12
Pg. 2289-2297
(Dec 2018)
ISSN: 1573-2584 [Electronic] Netherlands |
PMID | 30324576
(Publication Type: Journal Article, Observational Study)
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Chemical References |
- Antibodies
- Phosphates
- Triglycerides
- Platelet Factor 4
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Topics |
- Age Factors
- Aged
- Antibodies
(blood)
- Arteriovenous Shunt, Surgical
(adverse effects)
- Brain Ischemia
(complications, epidemiology)
- Cardiovascular Diseases
(epidemiology)
- Coronary Artery Disease
(epidemiology)
- Female
- Humans
- Longitudinal Studies
- Male
- Middle Aged
- Phosphates
(blood)
- Platelet Count
- Platelet Factor 4
(immunology)
- Renal Dialysis
- Renal Insufficiency, Chronic
(blood, therapy)
- Retrospective Studies
- Risk Factors
- Stroke
(epidemiology, etiology)
- Thrombocytopenia
(epidemiology)
- Thrombosis
(epidemiology, etiology)
- Triglycerides
(blood)
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