NOP7 interacts with β-catenin and activates β-catenin/TCF signaling in hepatocellular carcinoma cells.

Abstract

BACKGROUND:

The hyperactivation of β-catenin signaling is frequently observed in clinical hepatocellular carcinoma (HCC) samples. Further understanding the mechanisms involved in activating β-catenin/TCF signaling would benefit the treatment of HCC.

METHOD AND RESULTS:

Here, it was found that NOP7 was a binding partner of β-catenin. NOP7 strengthened the interaction between β-catenin and TCF4, which led to the activation of β-catenin/TCF signaling. The upregulation of NOP7 in HCC promoted the growth (in both liquid culture and soft agar) and migration of HCC cancer cells.

CONCLUSION:

Taken together, we have demonstrated the oncogenic functions of NOP7 in HCC, suggesting that targeting NOP7 would benefit the treatment of HCC.

• Authors: Nan Wu, Jing Zhao, Youhua Yuan, Chuanjia Lu, Wenjing Zhu, Qun Jiang
• Journal: OncoTargets and therapy (Onco Targets Ther) Vol. 11 Pg. 6369-6376 ( 2018) ISSN: 1178-6930 [Print] New Zealand
• PMID: 30319277 (Publication Type: Journal Article)