Abstract | AIMS: METHODS: Eligible patients with type 2 diabetes (T2DM) and CKD stage 4 (eGFR 15 to <30 mL/min/1.73 m2) were randomized 1:1 to receive once-daily oral dose of bardoxolone methyl (20 mg) or placebo. RESULTS: CONCLUSIONS:
Bardoxolone methyl resulted in significant weight loss in a generally obese patient population with T2DM and stage 4 CKD, with the magnitude and rate dependent on baseline BMI.
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Authors | Glenn M Chertow, Gerald B Appel, Geoffrey A Block, Melanie P Chin, Daniel W Coyne, Angie Goldsberry, Kamyar Kalantar-Zadeh, Colin J Meyer, Mark E Molitch, Pablo E Pergola, Philip Raskin, Arnold L Silva, Bruce Spinowitz, Stuart M Sprague, Peter Rossing |
Journal | Journal of diabetes and its complications
(J Diabetes Complications)
Vol. 32
Issue 12
Pg. 1113-1117
(Dec 2018)
ISSN: 1873-460X [Electronic] United States |
PMID | 30318163
(Publication Type: Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Copyright | Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Blood Glucose
- Glycated Hemoglobin A
- hemoglobin A1c protein, human
- Oleanolic Acid
- bardoxolone methyl
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Topics |
- Aged
- Blood Glucose
(drug effects, metabolism)
- Body Weight
(drug effects)
- Diabetes Mellitus, Type 2
(blood, complications, drug therapy)
- Diabetic Nephropathies
(blood, drug therapy, pathology)
- Disease Progression
- Double-Blind Method
- Female
- Glomerular Filtration Rate
(drug effects)
- Glycated Hemoglobin
(drug effects, metabolism)
- Humans
- Male
- Middle Aged
- Obesity
(blood, complications, drug therapy)
- Oleanolic Acid
(analogs & derivatives, pharmacology, therapeutic use)
- Renal Insufficiency, Chronic
(blood, drug therapy, pathology)
- Waist Circumference
(drug effects)
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