Bilateral costotransverse and local continuous chemotherapy approach for debridement, fixation, and fusion of contiguous multisegmental thoracic spinal tuberculosis: A retrospective study.

Abstract	The study aims to evaluate the clinical efficacy of bilateral costotransverse debridement, transpedicular fixation, fusion, and local continuous chemotherapy in 20 patients of contiguous multisegmental thoracic spinal tuberculosis (CMTSTB). We analyzed 20 patients with contiguous thoracic spinal tuberculosis (TB) who underwent surgery via bilateral costotransverse debridement, fusion, posterior instrumentation, and postural drainage with local continuous chemotherapy. The clinical outcomes were evaluated in terms of kyphotic angle, bone fusion, neurologic status, erythrocyte sedimentation rate (ESR), and intraoperative and postoperative complications. All of the patients (8M/12F), averaged 45.8 ± 15.6 years old. The mean duration of postoperative follow-up was 30.7 ± 4.0 months. There was no recurrent TB infection. The values of ESR returned to normal levels at final follow-up. All patients got bony fusion within 8.1 ± 2.3 months after surgery. The average preoperative Cobb angle was 39.9° ± 8.6°, correcting to 9.8° ± 2.3° postoperatively and 10.8° ± 2.3° at the last follow-up. All patients with neurological deficit had dramatic improvement at the final follow-up. Our results showed that bilateral costotransverse surgery and local continuous chemotherapy are feasible and effective procedures in the treatment of CMTSTB. The approach can provide radical debridement, rebuild spinal stability, and cure TB.
Authors	Xinhua Yin, Liang Yan, Ming Yang, Shichang Liu, Baorong He, Zhongkai Liu, Dingjun Hao
Journal	Medicine (Medicine (Baltimore)) Vol. 97 Issue 41 Pg. e12752 (Oct 2018) ISSN: 1536-5964 [Electronic] United States
PMID	30313081 (Publication Type: Evaluation Study, Journal Article)
Chemical References	Antitubercular Agents
Topics	Adult Aged Antitubercular Agents (administration & dosage) Blood Sedimentation Combined Modality Therapy Debridement (methods) Drainage, Postural (methods) Feasibility Studies Female Follow-Up Studies Humans Male Middle Aged Retrospective Studies Spinal Fusion (methods) Thoracic Vertebrae (surgery) Treatment Outcome Tuberculosis, Spinal (therapy) Young Adult

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