Synthesis of Chiral Carbo-Nanotweezers for Enantiospecific Recognition and DNA Duplex Winding in Cancer Cells.

Abstract

Targeting the DNA of tumor cells with small molecules may offer effective clinical strategies for transcriptional inhibition. We unveil synthesis and characterization of ∼20 nm chiral carbon nanoparticles for enantiospecific recognition of DNA. Our approach inculcates chirality in carbon nanoparticles by controlled tethering of minor groove binders, i.e., Tröger's base (TB). The chiral particles positively enriched the cellular nucleus in MCF-7 breast cancer cells, irrespective of the TB asymmetry tethered on the particle surface, but negatively induced chiral carbon nanoparticles exhibited improved efficiency at inhibiting cell growth. Further studies indicated that these chiral particles act as nanotweezers to perturb the genomic DNA and induce apoptosis cascade in cancer cells.

• Authors: Indu Tripathi, Santosh K Misra, Fatemeh Ostadhossein, Indrajit Srivastava, Dipanjan Pan
• Journal: ACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 10 Issue 44 Pg. 37886-37897 (Nov 07 2018) ISSN: 1944-8252 [Electronic] United States
• PMID: 30300544 (Publication Type: Journal Article)

Chemical References

• Charcoal
• DNA

Topics

• Cell Line, Tumor
• Cell Proliferation (drug effects)
• Charcoal (chemistry)
• DNA (chemistry, isolation & purification)
• DNA Damage (drug effects)
• Humans
• MCF-7 Cells
• Nanoparticles (administration & dosage, chemistry)
• Neoplasms (drug therapy, pathology)
• Stereoisomerism