Cardiac resynchronization therapy in congenital heart disease: Results from the German National Register for Congenital Heart Defects.

Abstract

BACKGROUND:

Cardiac resynchronization therapy (CRT) is an established option for patients with heart failure. Limited data exists on indications and outcome of CRT in contemporary congenital heart disease (CHD) patients.

METHODS AND RESULTS:

All patients with CRT registered in the German National Register for Congenital Heart Defects were systematically identified. We analysed data on demographics, type of congenital defect as well as repair, associated conditions, indication for CRT, heart failure medication, combination with a defibrillator or pacemaker and outcome. Overall, 65 patients with CRT were identified. The most common congenital diagnoses were Tetralogy of Fallot (n = 11), congenitally corrected transposition of the great arteries (ccTGA) (n = 9) and double outlet right ventricle (n = 6). The majority of patients (n = 48, 87%) had conventional antibradycardia pacing or ICD indications. Of these, the majority (n = 44) underwent an upgrade to a CRT system to avoid the detrimental consequences of longstanding conventional ventricular single-site pacing, whereas four patients required an ICD due to heart failure and a history of malignant ventricular tachycardia. During a median follow-up of 6.9 years 19 patients developed complications: 16 patients experienced pacemaker lead dysfunction and 3 patients pacemaker infection.

CONCLUSIONS:

The current study based on a large national register for CHD shows that CRT is feasible and can be used as an adjunct in the heart failure treatment of selected CHD patients. Uptake of this therapy proved to be low in this nationwide study and CRT implantation was largely used in patients with a pre-existing pacing indication or those requiring an ICD.

• Authors: Ann-Katrin Flügge, Kristina Wasmer, Stefan Orwat, Hashim Abdul-Khaliq, Paul C Helm, Ulrike Bauer, Helmut Baumgartner, Gerhard-Paul Diller, German Competence Network for Congenital Heart Defects Investigators
• Journal: International journal of cardiology (Int J Cardiol) Vol. 273 Pg. 108-111 (Dec 15 2018) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 30297188 (Publication Type: Journal Article)
• Copyright: Copyright © 2018. Published by Elsevier B.V.

Topics

• Adult
• Cardiac Resynchronization Therapy (methods, trends)
• Cohort Studies
• Female
• Germany (epidemiology)
• Heart Defects, Congenital (diagnosis, epidemiology, therapy)
• Humans
• Male
• Registries
• Retrospective Studies
• Young Adult