Quantitative MRI analysis of infrapatellar and suprapatellar fat pads in normal controls, moderate and end-stage osteoarthritis.

Abstract

The aim of this study was to analyze the magnetic resonance imaging (MRI) volumetric and morphometric characteristics of the infrapatellar fat pad (IFP) and the suprapatellar fat pad (SFP) in normal controls, moderate and end-stage osteoarthritis (OA) patients. Forty-four MRI images of the three groups were collected: a) 17 patients undergoing meniscectomy with Outerbridge score 0 (control group); b) 15 patients undergoing meniscectomy with Outerbridge score 3/4 (moderate OA group); and c) 12 patients undergoing total knee replacement (end-stage OA group). Volume, depth, femoral and tibial arch lengths of IFP were quantified. The hypointense IFP signals were also scored. The SFP volume, oblique, antero-posterior and cranio-caudal lengths were determined. IFP and SFP characteristics were compared between groups. A decrease of IFP volume, depth, femoral, and tibial arch lengths in moderate and end-stage OA compared to controls were observed. A difference in IFP hypointense signal was found between groups. No differences were found in SFP characteristics between the groups. In controls and moderate OA patients, correlations were found among the different MRI characteristics of both IFP and SFP, while in the end-stage OA group correlations were found only in SFP. We evidenced differences of the IFP MRI morphometric characteristics between the groups analyzed, supporting an important role of IFP in OA pathology and progression. On the contrary, no differences were highlighted in SFP analysis suggesting that this fat pad is not clearly involved in OA, probably due to its peculiar localization and different function.

• Authors: Chiara Giulia Fontanella, Elisa Belluzzi, Marco Rossato, Eleonora Olivotto, Giovanni Trisolino, Pietro Ruggieri, Alessandro Rubini, Andrea Porzionato, Arturo Natali, Raffaele De Caro, Roberto Vettor, Roberta Ramonda, Veronica Macchi, Marta Favero
• Journal: Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft (Ann Anat) Vol. 221 Pg. 108-114 (Jan 2019) ISSN: 1618-0402 [Electronic] Germany
• PMID: 30292837 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Elsevier GmbH. All rights reserved.

Topics

• Adipose Tissue (diagnostic imaging, pathology)
• Adult
• Aged
• Case-Control Studies
• Female
• Humans
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Osteoarthritis, Knee (diagnostic imaging, pathology)
• Patella (diagnostic imaging, pathology)
• Retrospective Studies
• Severity of Illness Index