Abstract |
We have determined the in vitro activity of antifungal, antibacterial, and antiprotozoal drugs alone and in combination against seven Conidiobolus lamprauges clinical isolates. The assays were based on the M38-A2 protocol and the checkerboard microdilution method. The lowest inhibitory concentrations were observed for amphotericin B, miconazole (MCZ), terbinafine, and miltefosine (MTF) (MIC range 0.25-1; 2-8; 0.25-2; 2-16 μg/ml, respectively). The main synergism observed was through the combination of azithromycin (AZI)+MTF and dapsone (DAP)+MTF (100%), AZI+DAP (85.7%), AZI+MCZ (57.1%) as well as MCZ plus CTX and DAP (42.9%). The in vitro activities suggest that the combination of MTF and AZI or DAP are promising candidate therapies for conidiobolomycosis.
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Authors | Josias R Stefanello, Fernanda B Piasentin, Juliana S M Tondolo, Erico S Loreto, Valéria Dutra, Sydney H Alves, Janio M Santurio |
Journal | Medical mycology
(Med Mycol)
(Oct 04 2018)
ISSN: 1460-2709 [Electronic] England |
PMID | 30289533
(Publication Type: Journal Article)
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