Genomic alterations driving psoriasis pathogenesis.

Abstract

Psoriasis is an immune mediated inflammatory skin disease with complex etiology involving interplay between environmental and genetic risk factors as disease initiating event. Enhanced understanding on genetic risk factors, differentially expressed genes, deregulated proteins and pathway-targeted therapeutics have established multiple axis of psoriasis pathogenesis. So far, loci in 424 genes are reported to be associated with psoriasis alongside copy number variations and epigenetic alterations. From clinical perspective, presence of specific genetic trigger(s) in individual psoriasis patient could aid in devising a personalized therapeutic strategy. Therefore, the review presents an updates on reported genomic alterations and their subsequent course of cutaneous inflammations that potentially drive to psoriasis.

• Authors: S Singh, D Pradhan, P Puri, V Ramesh, S Aggarwal, A Nayek, A K Jain
• Journal: Gene (Gene) Vol. 683 Pg. 61-71 (Jan 30 2019) ISSN: 1879-0038 [Electronic] Netherlands
• PMID: 30287254 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2018 Elsevier B.V. All rights reserved.

Topics

• DNA Copy Number Variations
• Epigenesis, Genetic
• Gene Regulatory Networks
• Genetic Predisposition to Disease
• Genetic Variation
• Humans
• Polymorphism, Single Nucleotide
• Precision Medicine
• Psoriasis (genetics)