Primary cardiac rhabdomyosarcoma developed after receiving radiotherapy for left breast cancer 18 years prior.

Abstract

The heart is an organ where primary malignant tumors rarely develop. In particular, the incidence of cardiac rhabdomyosarcoma (RMS) is extremely low. It has been reported that the risk of second malignant tumors in mediastinum is increased by radiotherapy in women with breast cancer. However, little is known about the association between irradiation to heart and cardiac RMS. Here, we report a case of a 68-year-old woman with primary cardiac RMS. She suddenly presented syncope at a workplace, and was taken to the emergency room at our hospital. Several imaging tests, including echocardiogram and cine magnetic resonance imaging, detected two tumors in the right ventricle (RV) and its outflow tract, which had almost obstructed the main trunk of the pulmonary artery (PA). To avoid sudden PA occlusion by the tumor, we emergently performed surgical excision of the tumors from the RV. Pathological analysis revealed that these tumors were embryonal type RMS. She had received radiotherapy after mastectomy for left breast cancer 18 years previously, and no recurrence of breast cancer had been detected. This cardiac RMS is considered as a second malignant tumor related to radiotherapy for breast cancer. <Learning objective: We experienced a 68-year-old woman having two tumors of the RMS in RV, who had received radiotherapy for left breast cancer 18 years previously and had previously presented no recurrence. There is literature suggesting that radiotherapy may increase the risk of soft-tissue sarcoma in women with breast cancer. We should be aware of cardiac RMS as a second malignant tumor related to radiotherapy for breast cancer, although its incidence is extremely low.>.

• Authors: Satomi Suehiro, Morihiro Matsuda, Taizo Hirata, Daiki Taniyama, Kazuya Kuraoka, Tai-Ichi Takasaki, Takatsugu Segawa, Toshiharu Oka, Ritsu Tamura, Hiroshi Sugino
• Journal: Journal of cardiology cases (J Cardiol Cases) Vol. 15 Issue 6 Pg. 181-183 (Jun 2017) ISSN: 1878-5409 [Print] Japan
• PMID: 30279774 (Publication Type: Case Reports)