Immunohistochemical characterization of lymphangiogenesis-related biomarkers in primary and recurrent gliomas: A STROBE compliant article.

Abstract

Glial tumors constitute the majority of primary intracranial brain tumors. The expression of specific markers of lymphangiogenesis in gliomas still remains unclear.A total of 40 surgical specimens from 20 patients with recurrent gliomas were included in the study. The expression of D2-40, vascular endothelial growth factor (VEGF)-C, VEGF-D, and VEGF receptor-3 (VEGR-3) was detected by immunohistochemistry (IHC). The clinicopathologic data (p53 and Ki67) were also collected and analyzed.At relapse malignant transformation rate was 65% (13/20 cases). D2-40, VEGF-C, VEGF-D, and VEGFR-3 were expressed in 20%, 30%, 60%, and 20% of primary and 45%, 30%, 75%, and 35% of recurrent glioma tumors (P < .01, P = 1.00, P = .03, P = .03). In 13 cases with increased malignancy grade, the expression of Ki67 and p53 were higher at relapse compared with the primary tumors (P = .001, P = .045). Multivariate survival analysis showed VEGF-D was an independent prognostic factor for malignant transformation (HR = 0.376, P = .045).Glioma is easy to relapse with tumor progression. VEGF-D was an independent prognostic factor for malignant transformation.

• Authors: Jun Jiang, Shun Wang, Yuan Chen, Chengwei Wang, Chuncheng Qu, Yuguang Liu
• Journal: Medicine (Medicine (Baltimore)) Vol. 97 Issue 39 Pg. e12458 (Sep 2018) ISSN: 1536-5964 [Electronic] United States
• PMID: 30278527 (Publication Type: Journal Article, Observational Study)

Chemical References

• Antibodies, Monoclonal, Murine-Derived
• Biomarkers
• Ki-67 Antigen
• Tumor Suppressor Protein p53
• VEGFD protein, human
• Vascular Endothelial Growth Factor A
• Vascular Endothelial Growth Factor D
• monoclonal antibody D2-40
• Receptors, Vascular Endothelial Growth Factor

Topics

• Adult
• Antibodies, Monoclonal, Murine-Derived (metabolism)
• Biomarkers (metabolism)
• Brain Neoplasms (diagnostic imaging, metabolism, pathology, surgery)
• Disease Progression
• Female
• Glioma (diagnostic imaging, metabolism, pathology, surgery)
• Humans
• Ki-67 Antigen (metabolism)
• Lymphangiogenesis (immunology)
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Neoplasm Recurrence, Local (diagnostic imaging, metabolism, pathology)
• Prognosis
• Receptors, Vascular Endothelial Growth Factor (metabolism)
• Survival Analysis
• Tumor Suppressor Protein p53 (metabolism)
• Vascular Endothelial Growth Factor A (metabolism)
• Vascular Endothelial Growth Factor D (metabolism)