Long non-coding RNA OGFRP1 regulates LYPD3 expression by sponging miR-124-3p and promotes non-small cell lung cancer progression.

Abstract

Long noncoding RNA (OGFRP1) has been reported to be involved in the progression of non-small cell lung cancer (NSCLC). However, the expression pattern, functions and molecular mechanisms of OGFRP1 in NSCLC remains unclear. In the present study, we found that OGFRP1 expression was significantly up-regulated in both NSCLC tissues and cell lines, and the upregulation of OGFRP1 expression is a powerful predictor of advanced clinical stage, lymph nodes metastasis and poor prognosis for NSCLC patients. Loss-of-function assay indicated that knockdown of OGFRP1 inhibited proliferation, migration and invasion, and induced apoptosis in vitro. Mechanistically, OGFRP1 could directly bind to miR-124-3p and effectively act as a competing endogenous RNA (ceRNA) for miR-124-3p to promote the expression of the target gene LYPD3. Taken together, OGFRP1 contributed to progression of NSCLC at least partly through upregulating LYPD3 expression by sponging miR-124-3p, indicating that OGFRP1 may be a novel prognostic biomarker and therapeutic target in NSCLC.

• Authors: Li-Xin Tang, Guo-Hua Chen, Huan Li, Ping He, Yan Zhang, Xue-Wen Xu
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 505 Issue 2 Pg. 578-585 (10 28 2018) ISSN: 1090-2104 [Electronic] United States
• PMID: 30274775 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Elsevier Inc. All rights reserved.

Chemical References

• Cell Adhesion Molecules
• GPI-Linked Proteins
• LYPD3 protein, human
• MIRN1243 microRNA, human
• MicroRNAs
• RNA, Long Noncoding

Topics

• Carcinoma, Non-Small-Cell Lung (genetics, metabolism, mortality, pathology)
• Cell Adhesion Molecules (genetics, metabolism)
• Cell Line, Tumor
• Disease Progression
• GPI-Linked Proteins (genetics, metabolism)
• Gene Expression Regulation, Neoplastic
• Humans
• Lung Neoplasms (genetics, metabolism, mortality, pathology)
• MicroRNAs (metabolism)
• Prognosis
• RNA, Long Noncoding (metabolism)