Electrospun mucosal wound dressings containing styptics for bleeding control.

Abstract

Two major aspects need to be focused to accelerate wound healing of mucosal damages especially in the field of otorhinolaryngology. (i) The problem of application due to the small access during surgery, (ii) the fixation of the wound dressing to reveal a stable healing process. In the present work the high request to a mucosal wound dressing which additionally support hemostasis was addressed. We developed an electrospun fabric made of poly(l-lactide-co-d/l-lactide) (PLA) which can be loaded with the hemostatic agents adrenaline and tranexamic acid to cover mucosal lesions analogues to common skin patches. These loaded electrospun fabrics were demonstrated to be biocompatible, thin and flexible, and thus could be adapted individually to the mucosal defect with respect to localization and size of the lesion. The treatment of mucosal defects with these loaded PLA wound dressings induced a faster and time controlled hemostatic reaction, which significantly improved the healing process.

• Authors: Ralf Wyrwa, Katja Otto, Sibylle Voigt, Astrid Enkelmann, Matthias Schnabelrauch, Thomas Neubert, Gerlind Schneider
• Journal: Materials science & engineering. C, Materials for biological applications (Mater Sci Eng C Mater Biol Appl) Vol. 93 Pg. 419-428 (Dec 01 2018) ISSN: 1873-0191 [Electronic] Netherlands
• PMID: 30274074 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Elsevier B.V. All rights reserved.

Chemical References

• Polyesters
• poly(lactide)

Topics

• Animals
• Bandages
• Female
• HeLa Cells
• Humans
• Mice
• Polyesters (chemistry, pharmacology)
• Rabbits
• Respiratory Mucosa (injuries, pathology)
• Wound Healing