Multi-drug resistant Mycobacterium tuberculosis & oxidative stress complexity: Emerging need for novel drug delivery approaches.

Abstract

Tuberculosis (caused by Mycobacterium tuberculosis, Mtb) treatment involves multiple drug regimens for a prolonged period. However, the therapeutic benefit is often limited by poor patient compliance, subsequently leading to treatment failure and development of antibiotic resistance. Notably, oxidative stress is a crucial underlying factor that adversely influences the various treatment regimens in tuberculosis. Little information is available with advanced drug delivery systems that could be effectively utilized, in particular, for targeting the oxidative stress in tuberculosis. Thus, this presents an opportunity to review the utility of various available, controlled-release drug delivery systems (e.g., microspheres, liposomes, niosomes, solid lipid nanoparticles, dendrimers) that could be beneficial in tuberculosis treatments. This will help the biological and formulation scientists to pave a new path in formulating a treatment regimen for multi-drug resistant Mtb.

• Authors: Kamal Dua, Vamshi Krishna Rapalli, Shakti Dhar Shukla, Gautam Singhvi, Madhur D Shastri, Dinesh Kumar Chellappan, Saurabh Satija, Meenu Mehta, Monica Gulati, Terezinha De Jesus Andreoli Pinto, Gaurav Gupta, Philip M Hansbro
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 107 Pg. 1218-1229 (Nov 2018) ISSN: 1950-6007 [Electronic] France
• PMID: 30257336 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Chemical References

• Antitubercular Agents
• Delayed-Action Preparations

Topics

• Animals
• Antitubercular Agents (administration & dosage, pharmacology)
• Delayed-Action Preparations
• Drug Delivery Systems
• Humans
• Mycobacterium tuberculosis (drug effects, isolation & purification)
• Oxidative Stress (drug effects)
• Tuberculosis, Multidrug-Resistant (drug therapy)