Abstract | BACKGROUND: RESULTS: Ap mice demonstrated significantly greater SMG and sublingual gland (SMG/SLG complex) mass/ body weight and percentage of parenchyma per unit area of the SMG compared with control mice. Furthermore, gene expression of Fgf1, Fgf2, Fgf3, Pdgfra, Pdgfrb, Mmp2, Bmp4, Lama5, Etv5, and Dusp6 was significantly higher in the SMG/SLG complex of Ap mice. FGF3 and BMP4 exhibited altered detection patterns. The numbers of macrophages were significantly greater in SMGs of Ap mice than in controls. Regarding functional evaluations of the salivary glands, no significant differences were observed. CONCLUSIONS: These results suggest that the gain-of-function mutation in FGFR2 in the SMGs of Ap mice enhances branching morphogenesis. Developmental Dynamics 247:1175-1185, 2018. © 2018 Wiley Periodicals, Inc.
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Authors | Kojiro Yamaji, Jumpei Morita, Tsukasa Watanabe, Kaori Gunjigake, Mitsushiro Nakatomi, Momotoshi Shiga, Kentaro Ono, Keiji Moriyama, Tatsuo Kawamoto |
Journal | Developmental dynamics : an official publication of the American Association of Anatomists
(Dev Dyn)
Vol. 247
Issue 11
Pg. 1175-1185
(11 2018)
ISSN: 1097-0177 [Electronic] United States |
PMID | 30251381
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2018 Wiley Periodicals, Inc. |
Chemical References |
- Bmp4 protein, mouse
- Bone Morphogenetic Protein 4
- Fgf3 protein, mouse
- Fibroblast Growth Factor 3
- Fgfr2 protein, mouse
- Receptor, Fibroblast Growth Factor, Type 2
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Topics |
- Acrocephalosyndactylia
(genetics, pathology)
- Animals
- Bone Morphogenetic Protein 4
(metabolism)
- Cell Count
- Disease Models, Animal
- Fibroblast Growth Factor 3
(metabolism)
- Gain of Function Mutation
- Macrophages
(pathology)
- Mice
- Morphogenesis
- Receptor, Fibroblast Growth Factor, Type 2
(genetics)
- Submandibular Gland
(abnormalities, growth & development)
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