Abstract |
Null cell adenoma is composed of adenohypophyseal cells that show no evidence of any specific cell type differentiation by immunohistochemistry or transcription factors like pituitary-specific positive transcription factor 1 and steroidogenic factor 1. Though rare, pituitary ependymoma and germinoma are also known to occur at sellar region and in such instances, it is challenging to differentiate them from a pituitary null cell adenoma featuring papillary architecture and perivascular pseudo-rosettes. We describe a case of an elderly diabetic lady presenting with headache and blurring of vision for past 3 months due to a sellar tumour. The histology was diagnostically challenging with notable presence of numerous perivascular pseudo-rosettes and negative immunoreactivity for all pituitary hormones. The differential diagnosis and importance of ancillary techniques is discussed.
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Authors | Vikram Singh, Kirti Gupta, Pravin Salunke, Sivashanmugam S Dhandapani |
Journal | Head and neck pathology
(Head Neck Pathol)
Vol. 13
Issue 4
Pg. 677-680
(Dec 2019)
ISSN: 1936-0568 [Electronic] United States |
PMID | 30251033
(Publication Type: Case Reports, Journal Article)
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Topics |
- Adenoma
(diagnosis, pathology)
- Female
- Humans
- Immunohistochemistry
- Middle Aged
- Pituitary Neoplasms
(diagnosis, pathology)
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