Reprint of: Pathologic manifestations of Immunoglobulin(Ig)G4-related lung disease.

Abstract

Immunoglobulin(Ig)G4-related disease (IgG4-RD) is a fibroinflammatory condition that can affect virtually any organ and usually presents as tumefactive lesions involving multiple sites. Characteristic histopathology of IgG4-RD consists of dense lymphoplasmacytic infiltrate, fibrosis (often in storiform pattern), and obliterative phlebitis, accompanied by tissue infiltration of IgG4-positive plasma cells with or without elevation of serum IgG4 level. Despite a general similarity in the morphologic manifestations of IgG4-RD, site-specific unique morphologic features have been described in some organs including the lung. Compared with other sites, pulmonary involvement by IgG4-RD has been recognized more recently, and lung biopsy interpretation for this condition is often challenging, as both a relative paucity of pathognomonic features and a plethora of overlapping findings with other fibroinflammatory processes of the lung. This review is focused on the morphologic spectrum of IgG4-related lung disease documented in the current literature and on the pertinent issues in the differential diagnoses with other conditions encountered in the lung.

• Authors: Eunhee S Yi, Hiroshi Sekiguchi, Tobias Peikert, Jay H Ryu, Thomas V Colby
• Journal: Seminars in diagnostic pathology (Semin Diagn Pathol) Vol. 35 Issue 5 Pg. 347-351 (Sep 2018) ISSN: 0740-2570 [Print] United States
• PMID: 30249368 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.