Circulating microRNAs are upregulated following acute aerobic exercise in obese individuals.

Abstract

INTRODUCTION/PURPOSE:

MicroRNAs (miRNAs), a class of non-coding RNAs, are involved in the regulation of gene expression and numerous biological processes, including inflammation and metabolism in obese populations. Emerging research indicates that physical activity provides health-related benefits in obesity-associated inflammatory diseases. This study examined how acute aerobic exercise would mediate the changes in plasma level of inflammation-related circulating miRNA (ci-miRNA) expression (miR-21, miR-126, miR-130b, miR-221, and miR-222) in obese and normal-weight subjects.

METHODS:

Twenty-four subjects (12 obese and 12 normal-weight) were recruited to participate in a 30-min aerobic exercise (75% VO2max). Blood samples were taken prior to exercise, immediately following exercise, 1 h, and 2 h into recovery for analysis of target ci-miRNAs in plasma.

RESULTS:

A higher baseline levels of ci-miRNAs (miR-126, miR-130b, miR-221, and miR-222) were found in obese subjects than normal-weight subjects. In response to acute aerobic exercise, obese subjects exhibited a higher increase in plasma level of all ci-miRNAs: miR-21, miR-126, miR-130b, miR-221 and miR-222, even after controlling for VO2max and insulin resistance (HOMA-IR). Furthermore, all miRNA area-under-the curves "with respect to increase" (AUCi) were higher in obese subjects and also positively correlated with each other, even after controlling for VO2max and HOMA-IR.

CONCLUSION:

These findings indicate that acute aerobic exercise elicits a higher elevation in plasma level of inflammatory ci-miRNAs in obese than normal-weight individuals, irrespective of cardiorespiratory fitness and indicator of metabolic syndrome (HOMA-IR).

• Authors: Fanchen Bao, Aaron L Slusher, Michael Whitehurst, Chun-Jung Huang
• Journal: Physiology & behavior (Physiol Behav) Vol. 197 Pg. 15-21 (12 01 2018) ISSN: 1873-507X [Electronic] United States
• PMID: 30248300 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Circulating MicroRNA

Topics

• Adolescent
• Adult
• Biomarkers (blood)
• Circulating MicroRNA (blood)
• Exercise (physiology)
• Female
• Humans
• Male
• Obesity (blood, immunology)
• Young Adult