Differentiation of Predominantly Solid Enhancing Lipid-Poor Renal Cell Masses by Use of Contrast-Enhanced CT: Evaluating the Role of Texture in Tumor Subtyping.

Abstract

OBJECTIVE:

The purpose of this study was to assess the accuracy of a panel of texture features extracted from clinical CT in differentiating benign from malignant solid enhancing lipid-poor renal masses.

MATERIALS AND METHODS:

In a retrospective case-control study of 174 patients with predominantly solid nonmacroscopic fat-containing enhancing renal masses, 129 cases of malignant renal cell carcinoma were found, including clear cell, papillary, and chromophobe subtypes. Benign renal masses-oncocytoma and lipid-poor angiomyolipoma-were found in 45 patients. Whole-lesion ROIs were manually segmented and coregistered from the standard-of-care multiphase contrast-enhanced CT (CECT) scans of these patients. Pathologic diagnosis of all tumors was obtained after surgical resection. CECT images of the renal masses were used as inputs to a CECT texture analysis panel comprising 31 texture metrics derived with six texture methods. Stepwise logistic regression analysis was used to select the best predictor among all candidate predictors from each of the texture methods, and their performance was quantified by AUC.

RESULTS:

Among the texture predictors aiding renal mass subtyping were entropy, entropy of fast-Fourier transform magnitude, mean, uniformity, information measure of correlation 2, and sum of averages. These metrics had AUC values ranging from good (0.80) to excellent (0.98) across the various subtype comparisons. The overall CECT-based tumor texture model had an AUC of 0.87 (p < 0.05) for differentiating benign from malignant renal masses.

CONCLUSION:

The CT texture statistical model studied was accurate for differentiating benign from malignant solid enhancing lipid-poor renal masses.

• Authors: Bino A Varghese, Frank Chen, Darryl H Hwang, Steven Y Cen, Bhushan Desai, Inderbir S Gill, Vinay A Duddalwar
• Journal: AJR. American journal of roentgenology (AJR Am J Roentgenol) Vol. 211 Issue 6 Pg. W288-W296 (12 2018) ISSN: 1546-3141 [Electronic] United States
• PMID: 30240299 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contrast Media
• Lipids

Topics

• Adenoma, Oxyphilic (diagnostic imaging)
• Angiomyolipoma (diagnostic imaging)
• Carcinoma, Renal Cell (diagnostic imaging, pathology, surgery)
• Contrast Media
• Diagnosis, Differential
• Humans
• Kidney Neoplasms (diagnostic imaging, pathology, surgery)
• Lipids
• Logistic Models
• Reproducibility of Results
• Retrospective Studies
• Sensitivity and Specificity
• Tomography, X-Ray Computed